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The critical role of exosomes in tumor biology
Author(s) -
Jiang Keqiu,
Dong Chengyong,
Yin Zeli,
Li Rui,
Wang Qi,
Wang Liming
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27813
Subject(s) - microvesicles , biogenesis , function (biology) , extracellular vesicles , microbiology and biotechnology , biology , secretion , nucleic acid , exosome , microrna , computational biology , biochemistry , gene
Exosomes are a type of extracellular vesicles (diameter, 30‐160 nm), which contain multiple proteins, nucleic acids, lipid molecules, and other substances. Most types of cells can secrete exosomes, although the biogenesis, composition, and function is specific to different cell types. Recently, many studies have demonstrated that exosomes play a critical role in tumor development. In this review, we briefly summarize the biogenesis, composition, and function of exosomes. We also discuss the recent advances in the critical role of exosomes in tumor biology with a special focus on their application in tumor diagnosis and treatment.