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Role of thrombin in the pathogenesis of atherosclerosis
Author(s) -
Jaberi Najmeh,
Soleimani Atena,
Pashirzad Mehran,
Abdeahad Hosein,
Mohammadi Fariba,
Khoshakhlagh Mahdieh,
Khazaei Majid,
Ferns Gordon A,
Avan Amir,
Hassanian Seyed Mahdi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27771
Subject(s) - proinflammatory cytokine , thrombin , pathogenesis , inflammation , serine protease , medicine , immunology , discovery and development of direct thrombin inhibitors , cancer research , pharmacology , protease , biology , platelet , enzyme , biochemistry
Atherosclerosis is an arterial disease associated with inflammation. Thrombin is a procoagulant and proinflammatory serine protease that contributes to the pathology of atherosclerosis by enhancing the expression of cell adhesion molecules, inducing the secretion of proinflammatory cytokines, activating inflammatory responses in atherosclerotic plaques, stimulating proliferation of aortic smooth muscle cells, and exacerbating vascular lesions at sites of injury. Hence, thrombin appears to be an important target for treatment of atherosclerosis and thrombin pharmacological inhibitors have significant therapeutic potency for suppressing inflammatory responses in cardiovascular diseases. This review summarizes the proinflammatory signaling functions of thrombin as well as the therapeutic potency of thrombin inhibitors in the pathogenesis of atherosclerosis and hence their potential therapeutic value in this condition.