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Effect of sex hormone–binding globulin polymorphisms on the outcome of in vitro fertilization‐embryo transfer for polycystic ovary syndrome patients: A case‐control study
Author(s) -
Liu Yang,
Zhao XiXi,
Hu XiangJuan,
Yang Feng,
Lin Ping,
Cui ShiChang,
Zhao Wei,
Cao XiaoYun,
Wang YongSheng
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27756
Subject(s) - sex hormone binding globulin , polycystic ovary , ovarian hyperstimulation syndrome , infertility , follicular fluid , endocrinology , medicine , embryo transfer , hyperandrogenism , testosterone (patch) , unexplained infertility , in vitro fertilisation , biology , gynecology , pregnancy , androgen , hormone , insulin , insulin resistance , embryo , oocyte , microbiology and biotechnology , genetics
Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone–binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization‐embryo transfer (IVF‐ET) in PCOS patients. PCOS patients who underwent IVF‐ET and patients with non–PCOS‐related infertility were selected in the study. Correlations of SHBG rs6259 and rs727428 with the risk factors in PCOS were analyzed, followed by the evaluation of the effect of SHBG polymorphisms on the outcome of IVF‐ET in PCOS patients. At last, unconditional logistic regression analysis was performed to study the risk factors for IVF‐ET treatment outcome. Compared with SHBG rs6259 GG carriers, the incidence of PCOS was found to be elevated in SHBG rs6259 GA+AA carriers which indicated that the A allele was a risk factor for PCOS. Compared with SHBG rs6259 TT carriers, the number of retrieved oocytes and embryo as well as the fertility rate in SHBG rs6259 GA+AA carriers was found to be decreased, while the abortion rate, incidence of ovarian hyperstimulation syndrome, transplant rejection rate, estradiol, and testosterone in serum, as well as testosterone in follicular fluid were elevated. The luteal hormone, serum testosterone, and progesterone and GA+AA genotype of rs6259 were the risk factors for IVF‐ET treatment outcome. Taken together, the study showed that SHBG rs6259 polymorphisms might be correlated with the risk of PCOS and the outcome of IVF‐ET treatment.