Premium
Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40 432 subjects
Author(s) -
Jin Hongyan,
Huang Yupeng,
Yang Guokang
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27749
Subject(s) - meta analysis , odds ratio , genetic model , allele , confidence interval , medicine , polymorphism (computer science) , subgroup analysis , gastroenterology , genetics , biology , gene
Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN.Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α‐adducin rs4961 polymorphism and HTN.Results: A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α‐adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model: P = 0.003; allele model: P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α‐adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model: P < 0.0001; additive model: P = 0.01; allele model: P < 0.0001) and REMs (dominant model: P = 0.0005; additive model: P = 0.03; allele model: P = 0.0006).Conclusions: Our findings indicate that the α‐adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.