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The study of the serum level of IL‐4, TGF‐β, IFN‐γ, and IL‐6 in overweight patients with and without diabetes mellitus and hypertension
Author(s) -
Asadikaram Gholamreza,
Ram Maryam,
Izadi Alireza,
Sheikh Fathollahi Mahmood,
Nematollahi Mohammad Hadi,
Najafipour Hamid,
Shahoozehi Bidollah,
Mirhoseini Mahboobeh,
Masoumi Mohammad,
Shahrokhi Nader,
Arababadi Mohammad Kazemi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27700
Subject(s) - medicine , pathogenesis , overweight , diabetes mellitus , endocrinology , proinflammatory cytokine , obesity , cytokine , population , immunology , inflammation , environmental health
Background Obesity increases the risk of diabetes mellitus (DM) and hypertension. We aimed to analyze the serum levels of cytokines that have relevance to the pathologies including, interleukin‐4 (IL‐4), transforming growth factor‐β (TGF‐β), interferon‐γ (IFN‐γ), and IL‐6 cytokines of overweight men with DM and/or hypertension. Methods The study collected serum from 164 men. The sample population contained, 54 overweight men without DM or hypertension (control [CTL] group), 36 men with both DM and hypertension (DH group), 20 men with DM but no hypertension (D group), and 54 had hypertension without DM (H). Results The main results showed that the concentration of IFN‐γ in the DH group was significantly higher than the D, H, and CTL groups, IL‐6 in DH and D groups was significantly lower than the CTL group. The serum level of TGF‐β and IL‐4 cytokines did not show any significant differences across the four groups. Serum levels of IL‐6 were also significantly lower in untreated patients in D group than controls and in DH when compared with H groups. Conclusion In conclusion, it appears that the proinflammatory and anti‐inflammatory cytokines either play a significant role in the pathogenesis of hypertension and DM or serve as markers for these pathologies. Accordingly, increased serum levels of IFN‐γ may participate in the pathogenesis of hypertension in the diabetic patients and decreased IL‐6 is associated with type 2 DM.