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Disruption of the redox balance with either oxidative or anti‐oxidative overloading as a promising target for cancer therapy
Author(s) -
Farhood Bagher,
Najafi Masoud,
Salehi Eniseh,
Hashemi Goradel Nasser,
Nashtaei Maryam Shabani,
Khanlarkhani Neda,
Mortezaee Keywan
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27594
Subject(s) - oxidative stress , cancer cell , oxidative phosphorylation , cancer , cancer research , tumor microenvironment , cancer stem cell , immune system , biology , immunology , microbiology and biotechnology , medicine , biochemistry
Oxidative stress acts as a double‐edged sword by being both a promoter and a suppressor of cancer. Moderate oxidative stress is beneficial for cancer cell proliferative and invasiveness features, while overexposure of the cells to oxidative insults could induce cancer cell apoptosis and reduce hypoxia along with modulating the immune system for regression of tumor. Cancer cells and cancer stem cells have highly efficient redox systems that make them resistant to oxidative insults. The redox disruptive approach is an area of current research and key for oxidative targeted cancer therapies. This disruption is applicable by using either oxidative or anti‐oxidative overloading strategies, specifically on cancer cells without influencing normal cells or tissues around tumor. The activity of tumor suppressor cells within tumor microenvironment is needed to be maintained in patients receiving such approaches.