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No evidence for a major effect of three common polymorphisms of the GPx1 , MnSOD , and CAT genes on PCOS susceptibility
Author(s) -
Salahshoor Mohammad Reza,
Sohrabi Maryam,
Jalili Faramarz,
Jalili Parnian,
Rezavand Negin,
Haghnazari Lida,
Jalili Cyrus
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27564
Subject(s) - gpx1 , medicine , polycystic ovary , genotyping , endocrinology , hirsutism , allele , genetic predisposition , genotype , oxidative stress , biology , gene , genetics , catalase , insulin resistance , glutathione peroxidase , insulin , disease
Aim Polycystic ovary syndrome (PCOS) is one of the prevalent endocrine‐metabolic disorders. It is proposed that oxidative stress contributes to PCOS susceptibility and its metabolic associations. The current study aimed to investigate the influence of GPx1 (rs1050450), MnSOD (rs4880), and Catalase (rs1001179) variants with PCOS susceptibility, for the first time. Methods In a case‐control study, 350 Kurdish female volunteers (175 PCOS patients and 175 healthy controls) from Western Iran were studied. Genotyping for GPx1 and MnSOD were done using PCR‐RFLP and for CAT the allele‐specific PCR method was used. Results The percentage of patients suffering from hirsutism, acne, and acanthosis among patients with PCOS were 44.6%, 30.3%, and 14.9%, respectively. Distribution of alleles among patients suffering from PCOS versus healthy women was ‘Pro’ (69.1% vs 68.8%) and ‘Leu’ (31.4% vs 31.2%) for Gpx1 , ‘Ala’ (61.43% vs 56.57%) and ‘Val’ (38.57% vs 43.43%) for MnSOD , and ‘C’ (83.43% vs 84.57%) and ‘T’ (16.57% vs 15.43%) for CAT . Conclusion GPx1 (rs1050450), MnSOD (rs4880), and CAT (rs1001179) variants might not be a risk factor for PCOS.