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Potential roles of microRNAs in redox state: An update
Author(s) -
Yaribeygi Habib,
Atkin Stephen L.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27475
Subject(s) - oxidative stress , microrna , intracellular , microbiology and biotechnology , antioxidant , redox , oxidative phosphorylation , homeostasis , biology , chemistry , biochemistry , gene , organic chemistry
Oxidative stress is an important underlying cause of many disease processes and may arise due to either increasing free radical generation or decreasing antioxidant defense systems. MicroRNAs (miRs) are 22‐nucleotide non‐coding RNAs that may regulate many intracellular processes; and, more recently, they have been implicated in the pathways for free radical generation leading to oxidative stress. However, conversely, there is evidence that miRs may have an antioxidant effect, thus miR expression may be critical for the maintenance of the normal redox state and cell homeostasis. This review addresses these discrepant and opposing miR actions on how they may modify and regulate the oxidative balance.