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miR‐345‐5p regulates proliferation, cell cycle, and apoptosis of acute myeloid leukemia cells by targeting AKT2
Author(s) -
Ying Xiaoyang,
Zhang Wanggang,
Fang Meiyun,
Zhang Weijun,
Wang Chenchen,
Han Li
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27461
Subject(s) - myeloid leukemia , microrna , cancer research , haematopoiesis , leukemia , apoptosis , cell growth , epigenetics , akt2 , cell cycle , hematopoietic stem cell , myeloid , biology , akt1 , stem cell , medicine , immunology , microbiology and biotechnology , pi3k/akt/mtor pathway , gene , biochemistry , genetics
Acute myeloid leukemia (AML) is a malignant clonal hematopoietic disease, which is caused by hematopoietic stem cell abnormalities. Epigenetic regulation, especially of microRNAs (miRNAs), mostly results from external or environmental effects and is critical to AML. In this study, for the first time, we report that decreased expression of miR‐345‐5p facilitates the proliferation of leukemia cells in AML. Further study demonstrated that AKT1/2 was the target of miR‐345‐5p and was responsible for the dysregulation of leukemia cell proliferation and apoptosis. Inhibition of AKT1/2 ameliorated this malignant effect, which provides new insight into AML diagnosis, treatment, prognosis, and next‐step translational investigations.