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Low expression of ENC1 predicts a favorable prognosis in patients with ovarian cancer
Author(s) -
Fan Shaohua,
Wang Yanyan,
Sheng Ning,
Xie Ying,
Lu Jun,
Zhang Zifeng,
Shan Qun,
Wu Dongmei,
Sun Chunhui,
Li Mengqiu,
Hu Bin,
Zheng Yuanlin
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27447
Subject(s) - gene knockdown , ovarian cancer , messenger rna , cancer research , medicine , in vitro , endocrinology , cancer cell , cancer , biology , oncology , gene , genetics
Ectodermal‐neural cortex 1 (ENC1) belongs to a member of the kelch family of genes. It is an actin‐binding protein and plays a pivotal role in neuronal and adipocyte differentiation. Here, we found that lower expression of ENC1 in the ovarian cancer patients was associated with favorable prognosis. In addition, ENC1 was heterogeneously expressed in various ovarian cancer cells. The messenger RNA and protein expression levels of ENC1 in HO‐8910PM and NIH:OVCAR‐3 cells were obviously higher than that in the other types of ovarian cancer cells. Knockdown of ENC1 in HO‐8910PM or NIH:OVCAR‐3 cells could significantly increase the reactive oxygen species levels, resulting in inhibition of in vitro proliferation, migration, and invasion. Our findings suggest that decreasing expression of ENC1 may be a new approach that can be used for ovarian cancer treatment.