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Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases
Author(s) -
Aghaie Tayebe,
Jazayeri Mir Hadi,
Manian Mostafa,
Khani leila,
Erfani Marjan,
Rezayi Majid,
Ferns Gordon A.,
Avan Amir
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27415
Subject(s) - polyethylene glycol , biocompatibility , drug delivery , nanotechnology , colloidal gold , nanoparticle , drug , photodynamic therapy , blood–brain barrier , pharmacology , medicine , cancer research , biomedical engineering , materials science , chemistry , biochemistry , central nervous system , organic chemistry , metallurgy
Gold nanoparticles (GNs) have unique characteristics, for example, stability, biocompatibility, small dimensions, and low toxicity. Several clinical applications have been suggested for GNs, such as diagnosis, imaging, and drug delivery. GNs absorb infrared light, indicating their potential value for imaging. There is growing evidence showing the therapeutic application of GN for drug delivery because of their interaction with the blood‐brain barrier and DNA, the latter being associated with their genotoxic effects. GN can also be stimulated to produce high local temperatures, indicating their potential value in photodynamic therapy in the treatment of tumors. The aim of the current review is to summarize the potential applications of GNs in the biomedical field, specifically in neurodegenerative diseases.