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The expression of ubiquitin‐specific peptidase 8 and its prognostic role in patients with breast cancer
Author(s) -
Qiu Han,
Kong Jun,
Cheng Yunfei,
Li Gang
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27337
Subject(s) - breast cancer , nottingham prognostic index , oncology , medicine , estrogen receptor , carcinogenesis , clinical significance , biomarker , immunohistochemistry , proportional hazards model , survival analysis , cancer research , cancer , biology , genetics
Objectives To clarify the clinical relevance of ubiquitin‐specific protease 8 (USP8) for patients with breast cancer (BC). Methods Previous BC microarray studies GSE37751, GSE7390, and GSE21653 were reanalyzed to determine the USP8 levels between BC patients and the corresponding normal breast tissues and the correlation between USP8 expression and clinical features and clinical outcomes of patients with BC. Gene set enrichment analysis (GSEA) was conducted to investigate the potential mechanisms. Results USP8 was downregulated in BC cells compared with that in normal breast tissues ( P < 0.0001). The Χ 2 test and logistic regression analysis demonstrated that patients in USP8 high‐expression group were correlated with better clinical features (including histopathological grading, estrogen receptors, clinical risk group according to Nottingham prognostic index [NPI] criteria and clinical risk group according to Veridex signature) compared with patients in USP8 low‐expression group. Kaplan‐Meier survival and Cox proportional regression analysis suggested that USP8 predicted better survivals of BC patients in terms of distant metastasis‐free survival, time to distant metastasis, disease‐free survival, and overall survival. GSEA suggested that USP8 might impact the proliferation of BC cells through several biological processes associated tumorigenesis of BC. USP8 was significantly downregulated in BC patients ( P < 0.0001). Conclusions Our results demonstrated that USP8 might predict better clinical characteristics and might be a protective factor for patients with BC.