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Stem cell‐ and gene‐based therapies as potential candidates in Alzheimer's therapy
Author(s) -
Hosseini Seyede Atefe,
Mohammadi Rezvan,
Noruzi Somaye,
Mohamadi Yousef,
Azizian Mitra,
Mousavy Seyed Mojta,
Ghasemi Faezeh,
Hesari AmirReza,
Sahebkar Amirhossein,
Salarinia Reza,
Aghdam Arad Mobasher,
Mirzaei Hamed
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27202
Subject(s) - stem cell , stem cell therapy , embryonic stem cell , neural stem cell , mesenchymal stem cell , genetic enhancement , neurotrophic factors , medicine , neuroscience , disease , therapeutic approach , cancer research , biology , gene , pathology , microbiology and biotechnology , genetics , receptor
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such as encoding nerve growth factor, APOE , and glial cell–derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy.