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The role of high‐mobility group protein box 1 in lung cancer
Author(s) -
Wu XiaoJin,
Chen YuanYuan,
Gong ChanChan,
Pei DongSheng
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26837
Subject(s) - hmgb1 , high mobility group , lung cancer , transcription factor , nucleosome , chromatin , cancer research , biology , metastasis , biomarker , nuclear protein , chromatin remodeling , mediator , gene , inflammation , microbiology and biotechnology , cancer , medicine , immunology , genetics
High‐mobility group protein box 1(HMGB1)is a ubiquitous highly conserved nuclear protein. Acting as a chromatin‐binding factor, HMGB1 binds to DNA and plays an important role in stabilizing nucleosome formation, facilitating gene transcription, DNA repairing, inflammation, cell differentiation, and regulating the activity of steroid hormone receptors. Currently, HMGB1 is discovered to be related to development, progression, and targeted therapy of lung cancer, which makes it an attractive biomarker, and therapeutic target. This review aims to encapsulate the relationship between HMGB1 and lung cancer, suggesting that HMGB1 plays a pivotal role in initiation, development, invasion, metastasis, and prognosis of lung cancer.