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The role of lncRNAs in signaling pathway implicated in CC
Author(s) -
Yang Min,
Wang Min,
Li Xianping,
Xie Yixin,
Xia Xiaomeng,
Tian Jingjing,
Zhang Kan,
Tang Aiguo
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26835
Subject(s) - signal transduction , regulator , mapk/erk pathway , pi3k/akt/mtor pathway , biology , carcinogenesis , cancer research , malignancy , kinase , mechanism (biology) , bioinformatics , cancer , microbiology and biotechnology , genetics , gene , philosophy , epistemology
Cervical cancer (CC) is the second most common malignancy in females. Owing to poor diagnosis, resistance to the systemic therapies, and high recurrence rate, patients with CC have a relatively poor prognosis. The role of a signaling pathway in CC has always been the focus among worldwide researchers. As reported before, aberrant expression of proteins associated with signaling pathways, such as phosphatidylinositol 3‐kinase(PI3K), EGF‐R, β‐catenin, and Erk and Bcl‐2 was discovered in CC. Therefore, aberrant molecular signaling pathways are significant parts of cervical carcinogenesis. Recently discovered long noncoding RNAs (lncRNAs) as a new regulator player of molecular biology in CC have always been reported. In this review, we highlighted the role of lncRNA in signaling pathway implicated in CC and outlined the molecular mechanism of lncRNA in it. All of these present an opportunity for developing diagnosis and therapies against CC.