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Role of immune system in tumor progression and carcinogenesis
Author(s) -
Upadhyay Shishir,
Sharma Nidhi,
Gupta Kunj Bihari,
Dhiman Monisha
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26663
Subject(s) - immune system , immunotherapy , biology , acquired immune system , immunology , antigen , tumor progression , immune tolerance , cancer research , cancer , genetics
Tumor micro‐environment has potential to customize the behavior of the immune cell according to their need. In immune‐eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that helps in progression. In between eliminating and establishment phase, equilibrium and escaping phase regulate the immune cells response. During immune‐escaping, (1) the antigenic response generated is either inadequate, or focused entirely on tolerance, and (2) immune response generated is specific and effective, but the tumor skips immune recognition. In this review, we are discussing the critical role of immune cells and their cytokines before and after the establishment of tumor which might play a critical role during immunotherapy.