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Impact of IL‐22 and IL‐22 receptor alpha 1 polymorphisms on preeclampsia risk in Chinese Han women
Author(s) -
Niu Zhaoyuan,
Zhao Xin,
Liu Hongling,
Quan Jing,
Lin Yan,
Li Jing,
Wang Jingli,
Liu Mengchun,
Song Weiqing,
Chen Aiping,
Liu Shiguo
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26640
Subject(s) - single nucleotide polymorphism , genotype , odds ratio , allele , medicine , preeclampsia , allele frequency , polymorphism (computer science) , taqman , confidence interval , biology , immunology , gastroenterology , genetics , pregnancy , gene , real time polymerase chain reaction
Abstract Previous studies have indicated that an increased inflammatory response plays an important role in preeclampsia (PE), and rising levels of interleukin (IL)‐22 can trigger inflammation and hyperproliferation, leading to increased production of several pro‐inflammatory cytokines such as IL‐1, IL‐6, and IL‐8. We aimed to investigate the association between polymorphisms of IL‐22 and IL‐22 receptor alpha 1 gene (IL‐22RA1) and PE in Chinese Han population. Single nucleotide polymorphisms (SNPs) rs2227485 in IL‐22 and rs3795299 in IL‐22RA were genotyped by Taqman real‐time PCR in 1071 PE patients and 1263 control subjects. Differences in genetic distribution were compared between two groups using the chi‐square test. Significant differences were observed in genotypic and allelic frequencies of IL‐22RA1 rs3795299 between healthy controls and PE patients ( P < 0.001 by genotype; P = 0.001, odds ratio = 1.253, 95% confidence interval 1.103‐1.424 by allele). There were also significant differences in genotypic and allelic frequencies of rs3795299 between late‐onset/mild PE and control groups. In addition, we found obvious statistic difference for the allele of early‐onset PE/the genotype of late‐onset PE and control subgroups for IL‐22 rs2227485. IL‐22 rs2227485 and IL‐22RA1 rs3795299 may be associated with the development of PE in Chinese Han population. However, further validation is required in other populations, as well as an evaluation of the association of other SNPs in IL‐22 and IL‐22RA1 with PE.