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PI3K inhibitors IC87114 inhibits the migration and invasion of thyroid cancer cell in vitro and in vivo
Author(s) -
Jiang Yan,
Hao Shuai,
Tian Wuguo,
Gao Bo,
Zhang Xiaohua,
Zhang Shu,
Guo Lingji,
Yan Jie,
Luo Donglin
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26604
Subject(s) - in vivo , in vitro , pi3k/akt/mtor pathway , thyroid cancer , cancer research , cell migration , thyroid , cancer , cell , microbiology and biotechnology , chemistry , biology , medicine , endocrinology , signal transduction , biochemistry , genetics
Thyroid cancer is currently the most common endocrine malignancies, and PI3K/Akt pathway play an important role during its initiation and development. IC87114 is an inhibitor of PI3K/Akt pathway. Little is known about the role of IC87114 in the initiation and progression of thyroid cancer. Here, we demonstrated that IC87114 significantly inhibited both the migration and invasion of thyroid cancer cells, which can be mediated by inhibition of PI3K/Akt pathway. These results suggest that application of IC87114 may prove to be a particularly effective treatment for thyroid cancer.