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Neuroprotective effects of antioxidants in the management of neurodegenerative disorders: A literature review
Author(s) -
Panahi Yunes,
Rajaee Seyyed Mahdi,
Johnston Thomas P.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26536
Subject(s) - neurodegeneration , neuroprotection , oxidative stress , antioxidant , medicine , oxidative damage , neuroscience , pharmacology , bioinformatics , chemistry , biology , biochemistry , disease
It is proven that oxidative stress has a pivotal role in the process of neurodegeneration. The use of antioxidants is an attractive method to prevent the incidence of neurodegenerative diseases. We searched major databases (PubMed, Medline, and Google Scholar) using the keywords of neurodegeneration, oxidative stress, and antioxidant for both review and original studies, which have reported the various beneficial effects of antioxidants. About 70 studies were identified for this review. Among various antioxidants, nine antioxidants with the most applications in research investigations were selected and the major findings concerning their protective effects were reviewed. It is concluded that antioxidants can modify and readjust the oxidative stress in the biological milieu, elicit neuroprotective effects, and positively impact the management of neurodegenerative processes.