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Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol‐induced cardiac injury
Author(s) -
AlRasheed Nawal M.,
AlRasheed Nouf M.,
ALRabeeah Danah A.,
ALBarrak Heba S.,
ALSalman Salma A.,
Ibrahim Shahd A.,
ALHassab Sulafa A.,
AlAmin Maha A.,
Hasan Iman H.,
AlAjmi Hanaa N.,
ALShammari Tahani K.
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26530
Subject(s) - metformin , medicine , oxidative stress , cardioprotection , myocardial infarction , vitamin e , vitamin c , pharmacology , antioxidant , endocrinology , diabetes mellitus , chemistry , biochemistry
Several studies have reported that metformin is cardioprotective for diabetic and non‐diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti‐hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induction myocardial infarction (MI) in rats, using isoproterenol. Administration of metformin or vitamin E significantly reduced the cardiac mass index ( P < 0.01), ameliorated the changes to cardiac biomarkers, and attenuated oxidative stress levels compared to the isoproterenol group. Interestingly, combination therapy showed a slight synergistic effect. Histopathological analysis suggested that metformin treatment reduced NF‐κB expression and protected against isoproterenol‐induced MI. Our results indicate that metformin mediates a cardioprotective effect against isoproterenol‐induced MI via antioxidant activity and modulation of the NF‐κB signaling pathway. This suggests that metformin would be beneficial in MI treatment.