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Anoikis resistance and oncoviruses
Author(s) -
Kakavandi Ehsan,
Shahbahrami Ramin,
Goudarzi Hossein,
Eslami Gita,
Faghihloo Ebrahim
Publication year - 2018
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26363
Subject(s) - anoikis , metastasis , oncovirus , cancer research , cancer , biology , virus , immunology , hepatitis b virus , virology , genetics
Anoikis is known as a special type of programmed cell death which occurs in response to loss of correct cell‐extracellular matrix (ECM) connections. This process could be as pivotal event in normal development and tissue homeostasis and found as important mechanism in cancer invasiveness and metastasis. The persistent infection with oncoviruses including EBV (Epstein Bar virus), HPV (Human Papillomaviruses), HBV (Hepatitis B virus), KSHV (Human herpesvirus 8), HTLV‐1 (Human T‐lymphotropic virus‐1), and HCV (Hepatitis C virus) accounted as one of main risk factor for cancer progression. Some of them play critical roles in metastasis, especially in anoikis resistance which could contribute to metastasis of tumor cells. The better understanding of effects of oncoviruses on anoikis could contribute to finding of effective therapeutic platforms for treatment of virus‐associated cancers. This paper highlighted effects of these oncoviruses on anoikis protection in cancer.