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Evaluation of Prediction of Polymorphisms of DNA Repair Genes on the Efficacy of Platinum‐Based Chemotherapy in Patients With Non‐Small Cell Lung Cancer: A Network Meta‐Analysis
Author(s) -
Yu ShaoNan,
Liu GuiFeng,
Li XueFeng,
Fu BaoHong,
Dong LiXin,
Zhang ShuHua
Publication year - 2017
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26147
Subject(s) - ercc1 , xrcc3 , xrcc1 , oncology , medicine , single nucleotide polymorphism , lung cancer , nucleotide excision repair , dna repair , meta analysis , chemotherapy , biology , gene , genetics , genotype
This network meta‐analysis (NMA) was conducted to compare the predictive value of 14 SNPs in eight DNA repair genes on the efficacy of platinum‐based chemotherapy in patients with non‐small cell lung cancer (NSCLC). These included ERCC1 (rs11615, rs3212986, rs3212948), XRCC1 (rs25487, rs25489, rs1799782), XPD (rs13181, rs1799793), XPG (rs1047768, rs17655), XPA (rs1800975), XRCC3 (rs861539), APE1 (rs3136820), and RRM1 (rs1042858). The PubMed and Cochrane library databases were reviewed from their inception to February 2017 and studies which met our inclusion criteria were included in our investigation. This network meta‐analysis combines direct and indirect evidence to assess the predictive value of 14 SNPs in eight DNA repair genes on the efficacy of platinum‐based chemotherapy in NSCLC. We evaluated the predictive value through the use of the odd ratios (OR) and drawing surface under the cumulative ranking curves (SUCRA). A total of 26 eligible cohort studies were enrolled in this NMA. The pairwise meta‐analysis indicated that in terms of overall response ratio (ORR), ERCC1 (rs11615), XRCC1 (rs25487, rs1799782), and XPD (rs13181) polymorphisms are associated with the efficacy of platinum‐based chemotherapy in NSCLC. The result of this NMA suggests that there is no significant difference in predictive value of 8 DNA repair genes on the efficacy of platinum‐based chemotherapy in NSCLC patients. The rank of SUCRA values of the 14 SNPs in the eight DNA repair genes were: XPD (rs1799793)→ ERCC1 (rs3212986)→ XPA (rs1800975)→ ERCC1 (rs3212948)→ XRCC1 (rs25487)→ XRCC3 (rs861539)→ APE1 (rs3136820)→ ERCC1 (rs11615)→ XRCC1 (rs1799782)→ RRM1 (rs1042858)→ XPD (rs13181)→ XPG (rs1047768)→ XPG (rs17655)→ XRCC1 (rs25489). ERCC1 (rs11615), XRCC1 (rs25487, rs1799782) and XPD (rs13181) polymorphisms were better predictors in evaluating the efficacy of platinum‐based chemotherapy in NSCLC patients. J. Cell. Biochem. 118: 4782–4791, 2017. © 2017 Wiley Periodicals, Inc.