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Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes
Author(s) -
Hajavi Jafar,
Momtazi Amir Abbas,
Johnston Thomas P.,
Banach Maciej,
Majeed Muhammed,
Sahebkar Amirhossein
Publication year - 2017
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.26121
Subject(s) - adipokine , resistin , curcumin , adiponectin , type 2 diabetes , diabetes mellitus , insulin resistance , medicine , leptin , endocrinology , pharmacology , obesity
Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes and its comorbidities. J. Cell. Biochem. 118: 4170–4182, 2017. © 2017 Wiley Periodicals, Inc.