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Cells, Scaffolds and Their Interactions in Myocardial Tissue Regeneration
Author(s) -
Gorabi Armita Mahdavi,
Tafti Seyed Hossein Ahmadi,
Soleimani Masoud,
Panahi Yunes,
Sahebkar Amirhossein
Publication year - 2017
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25912
Subject(s) - regeneration (biology) , stem cell , microbiology and biotechnology , tissue engineering , regenerative medicine , mammalian heart , in vitro , myocyte , biology , biomedical engineering , medicine , biochemistry
Cardiac regenerative therapy includes several techniques to repair and replace damaged tissues and organs using cells, biomaterials, molecules, or a combination of these factors. Generation of heart muscle is the most important challenge in this field, although it is well known that new advances in stem cell isolation and culture techniques in bioreactors and synthesis of bioactive materials contribute to the creation of cardiac tissue regeneration in vitro. Some investigations in stem cell biology shows that stem cells are an important source for regeneration of heart muscle cells and blood vessels and can thus clinically contribute to the regeneration of damaged heart tissue. The aim of this review was to explain the principles and challenges of myocardial tissue regeneration with an emphasis on stem cells and scaffolds. J. Cell. Biochem. 118: 2454–2462, 2017. © 2017 Wiley Periodicals, Inc.