Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress | Zendy

Bahrami Afsane | Zendy; Amerizadeh Forouzan | Zendy; ShahidSales Soodabeh | Zendy; Khazaei Majid | Zendy; GhayourMobarhan Majid | Zendy; Sadeghnia Hamid Reza | Zendy; Maftouh Mina | Zendy; Hassanian Seyed Mahdi | Zendy; Avan Amir | Zendy

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Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress

Author(s) -

Bahrami Afsane,

Amerizadeh Forouzan,

ShahidSales Soodabeh,

Khazaei Majid,

GhayourMobarhan Majid,

Sadeghnia Hamid Reza,

Maftouh Mina,

Hassanian Seyed Mahdi,

Avan Amir

Publication year - 2017

Publication title -

journal of cellular biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.028

H-Index - 165

eISSN - 1097-4644

pISSN - 0730-2312

DOI - 10.1002/jcb.25903

Subject(s) - wnt signaling pathway , colorectal cancer , cancer research , curcumin , frizzled , medicine , signal transduction , cell growth , cancer , pharmacology , biology , microbiology and biotechnology , biochemistry

Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant activation of this pathway is associated with cell proliferation, invasive behaviors, and cell resistance, suggesting its potential value as a therapeutic target in treatment of CRC. Several agents have been developed for targeting of this pathway (e.g, natural agents: curcumin, 3,3‐diindolylmethane, phytoestrogen; Synthetic/small Wnt inhibitors: Rofecoxib; PRI‐724, CWP232291; and monoclonal antibody against frizzled receptors, Vanituctumab). This review summarizes the current knowledge about the therapeutic potential of targeting Wnt pathway with particular emphasis on preclinical/clinical studies in treatment of colorectal cancer. J. Cell. Biochem. 118: 1979–1983, 2017. © 2017 Wiley Periodicals, Inc.

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