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Formyl Peptide Receptors in Cellular Differentiation and Inflammatory Diseases
Author(s) -
Lee Ha Young,
Lee Mingyu,
Bae YoeSik
Publication year - 2017
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25877
Subject(s) - receptor , immune system , innate immune system , biology , myeloid , myeloid cells , inflammation , microbiology and biotechnology , immunology , biochemistry
Formyl peptide receptors (FPRs) are a family of classical chemoattractant receptors. Although FPRs are mainly expressed in phagocytic innate immune cells including monocytes/macrophages and neutrophils, recent reports demonstrated that additional different cell types such as T‐lymphocytes and several non‐immune cells also express functional FPRs. FPRs were first reported as a specific receptor to detect bacteria‐derived N‐formyl peptides. However, accumulating evidence has shown that FPRs can recognize various ligands derived from pathogens, mitochondria, and host. This review summarizes studies on some interesting endogenous agonists for FPRs. Here, we discuss functional roles of FPRs and their ligands concerning the regulation of cellular differentiation focusing on myeloid lineage cells. Accumulating evidence also suggests that FPRs may contribute to the control of inflammatory diseases. Here, we briefly review the current understanding of the functional role of FPRs and their ligands in inflammatory disorders in some animal disease models. J. Cell. Biochem. 118: 1300–1307, 2017. © 2017 Wiley Periodicals, Inc.