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Recent Advances in Mechanobiology of Osteosarcoma
Author(s) -
Adamopoulos Christos,
Gargalionis Antonios N.,
Piperi Christina,
Papavassiliou Athanasios G.
Publication year - 2017
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25660
Subject(s) - mechanobiology , osteosarcoma , mechanotransduction , mechanosensitive channels , intracellular , microbiology and biotechnology , signal transduction , biology , cell signaling , osteocyte , pathology , neuroscience , medicine , cancer research , osteoblast , in vitro , genetics , ion channel , receptor
Mechanotransduction is a key process by which cells perceive extracellular mechanical cues/intercellular physical interactions and transform them into intracellular biochemical signals. This physiological process is crucial during bone development and bone remodeling throughout childhood and adult life, whereas several aberrations during this process have emerged as a distinct pathogenic molecular entity in bone maladies and tumor formation. The present review focuses on recent advances regarding the mechanobiology of osteosarcoma, the most common type of bone cancer. Special emphasis is given on the mechano‐responsive signal transduction pathways underlying osteosarcoma pathology and on specific mechanosensitive molecules engaged in osteosarcoma development. J. Cell. Biochem. 118: 232–236, 2017. © 2016 Wiley Periodicals, Inc.