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The Multifaceted Osteoclast; Far and Beyond Bone Resorption
Author(s) -
Drissi Hicham,
Sanjay Archana
Publication year - 2016
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25560
Subject(s) - osteoclast , bone resorption , bone remodeling period , bone remodeling , angiogenesis , microbiology and biotechnology , osteolysis , bone cell , neuroscience , chemistry , biology , cancer research , medicine , endocrinology , receptor , surgery
The accepted function of the bone resorbing cell, osteoclast, has been linked to bone remodeling and pathological osteolysis. Emerging evidence points to novel functions of osteoclasts in controlling bone formation and angiogenesis. Thus, while the concept of a “clastokine” with the potential to regulate osteogenesis during remodeling did not come as a surprise, new evidence provided unique insight into the mechanisms underlying osteoclastic control of bone formation. The question still remains as to whether osteoclast precursors or a unique trap positive mononuclear cell, can govern any aspect of bone formation. The novel paradigm eloquently proposed by leaders in the field brings together the concept of clastokines and osteoclast precursor‐mediated bone formation, potentially though enhanced angiogenesis. These fascinating advances in osteoclast biology have motivated this short review, in which we discuss these new roles of osteoclasts. J. Cell. Biochem. 117: 1753–1756, 2016. © 2016 Wiley Periodicals, Inc.