Premium
Recombinant Mitochondrial Manganese Containing Superoxide Dismutase Protects Against Ochratoxin A‐Induced Nephrotoxicity
Author(s) -
Ciarcia Roberto,
Damiano Sara,
Squillacioti Caterina,
Mirabella Nicola,
Pagnini Ugo,
Florio Alessia,
Severino Lorella,
Capasso Giovambattista,
Borrelli Antonella,
Mancini Aldo,
Boffo Silvia,
Romano Gaetano,
Giordano Antonio,
Florio Salvatore
Publication year - 2016
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25425
Subject(s) - nephrotoxicity , superoxide dismutase , oxidative stress , ochratoxin a , lipid peroxidation , reactive oxygen species , catalase , renal function , chemistry , kidney , pharmacology , endocrinology , medicine , biochemistry , biology , food science , mycotoxin
Ochratoxin A (OTA) is a natural mycotoxin, involved in the development of important human and animal diseases. In this work we have studied the role of oxidative stress in the development of OTA nephrotoxicity and the effect of a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) to prevent kidney damage induced by OTA. Blood pressure, glomerular filtration rate and renal histology were analyzed in control rats and in OTA treated rats. In addition, lipid peroxidation, catalase and superoxide dismutase productions were measured. Our data showed that animals treated with OTA presented hypertension and reduction of glomerular filtration rate (GFR). These effects are most probably related to an increase in the reactive oxygen species (ROS) productions. In fact, we have shown that treatment with rMnSOD restored the levels of blood pressure and GFR simultaneously. Moreover, we have noted that OTA induced alteration on glomerular and tubular degeneration and interstitial infiltrates and that use of rMnSOD combined with OTA prevent this renal histological damage confirming the potential therapeutic role in the treatment of rMnSOD OTA nephrotoxicity. J. Cell. Biochem. 117: 1352–1358, 2016. © 2015 Wiley Periodicals, Inc.