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Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus
Author(s) -
Fritz Andrew J.,
Barutcu A. Rasim,
MartinBuley Lori,
van Wijnen André J.,
Zaidi Sayyed K.,
Imbalzano Anthony N.,
Lian Jane B.,
Stein Janet L.,
Stein Gary S.
Publication year - 2016
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25280
Subject(s) - interphase , chromosome , nucleus , function (biology) , biology , cell nucleus , microbiology and biotechnology , computational biology , evolutionary biology , neuroscience , genetics , gene
ABSTRACT The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear‐structure building blocks in directly supporting nuclear function in a physiologically responsive manner. J. Cell. Biochem. 117: 9–19, 2016. © 2015 Wiley Periodicals, Inc.