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Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer
Author(s) -
Eguchi Taka,
Prince Thomas,
Wegiel Barbara,
Calderwood Stuart K
Publication year - 2015
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25203
Subject(s) - sumo protein , zinc finger , myeloid leukemia , cancer research , zinc finger transcription factor , transcription factor , myeloid , phosphorylation , biology , repressor , chemistry , medicine , microbiology and biotechnology , genetics , ubiquitin , gene
Myeloid zinc finger 1 (MZF1) belongs to the SCAN‐Zinc Finger (SCAN‐ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co‐activators and co‐repressors. J. Cell. Biochem. 116: 2146–2154, 2015. © 2015 Wiley Periodicals, Inc.