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Prevention of Nephrotoxicity Induced by Cyclosporine‐A: Role of Antioxidants
Author(s) -
Damiano Sara,
Ciarcia Roberto,
Montagnaro Serena,
Pagnini Ugo,
Garofano Tiziana,
Capasso Giovambattista,
Florio Salvatore,
Giordano Antonio
Publication year - 2015
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.25022
Subject(s) - nephrotoxicity , pharmacology , medicine , drug , mechanism of action , kidney , chemistry , biochemistry , in vitro
ABSTRACT Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity are not clear, but several studies suggest the possible involvement of free radicals. In this review we have summarized the effect of some antioxidants that we have used in the recent years, in combination with CsA, to better understand the exact mechanism of action of CsA and to try to open new perspectives in the treatment of CsA nephrotoxicity. J. Cell. Biochem. 116: 364–369, 2015. © 2014 Wiley Periodicals, Inc.