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Epigenetic DNA Methylation in Radiation Biology: On the Field or on the Sidelines?
Author(s) -
Zielske Steven P.
Publication year - 2015
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24959
Subject(s) - reprogramming , epigenetics , dna methylation , context (archaeology) , biology , radiation therapy , dnmt1 , cancer research , radiation exposure , methylation , dna , computational biology , genetics , cell , methyltransferase , medicine , gene , gene expression , paleontology , nuclear medicine
DNA methylation has been studied with regard to chemotherapeutics for a number of years. The radiation field has just begun to look at this in the context of radiotherapy or radiation exposure. So far, the data suggest that radiation induces epigenetic reprogramming which indicates a purposeful response that influences the cell fate or alters the response to future exposure. Further studies may result in discovery of biomarkers for radiotherapy outcome or prediction of the degree of radiation resistance. Past and ongoing development of DNMT1 inhibitors that lead to DNA hypomethylation appear to sensitize many tumor types to radiation and may be an area with long term clinical implications. J. Cell. Biochem. 116: 212–217, 2015. © 2014 Wiley Periodicals, Inc.