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Effects of cigarette smoking on HDL quantity and function: Implications for atherosclerosis
Author(s) -
He Baimei,
Zhao Shuiping,
Peng Zhenyu
Publication year - 2013
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24581
Subject(s) - cholesterol , lecithin , cholesterylester transfer protein , medicine , cigarette smoking , high density lipoprotein , sterol o acyltransferase , reverse cholesterol transport , hepatic lipase , endocrinology , population , risk factor , lipoprotein , dysfunctional family , lipoprotein lipase , chemistry , biochemistry , environmental health , adipose tissue , clinical psychology
Cigarette smoking has been identified as an independent and preventable risk factor for atherosclerosis and cardiovascular disease. Population studies have shown that plasma high density lipoprotein (HDL) cholesterol levels are inversely related to the risk of developing cardiovascular disease. Cigarette smoking is associated with reduced HDL cholesterol levels. Cigarette smoking can alter the critical enzymes of lipid transport, lowering lecithin: cholesterol acyltransferase (LCAT) activity and altering cholesterol ester transfer protein (CETP) and hepatic lipase activity, which attributes to its impact on HDL metabolism and HDL subfractions distribution. In addition, HDL is susceptible to oxidative modifications by cigarette smoking, which makes HDL become dysfunctional and lose its atheroprotective properties in smokers. Therefore, cigarette smoking has a negative impact on both HDL quantity and function, which can explain, in part, the increased risk of cardiovascular disease in smokers. J. Cell. Biochem. 114: 2431–2436, 2013. © 2013 Wiley Periodicals, Inc.