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Haemostatic role of intermediate filaments in adhered platelets: Importance of the membranous system stability
Author(s) -
Cerecedo Doris,
MartínezVieyra Ivette,
Mondragón Ricardo,
Mondragón Mónica,
González Sirenia,
Galván Iván J.
Publication year - 2013
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24546
Subject(s) - platelet , cytoskeleton , coagulation , actin , microbiology and biotechnology , microtubule , organelle , chemistry , biophysics , platelet activation , dense granule , secretion , adhesion , platelet adhesiveness , granule (geology) , platelet aggregation , cell , biology , biochemistry , immunology , medicine , organic chemistry , paleontology
The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored. J. Cell. Biochem. 114: 2050–2060, 2013. © 2013 Wiley Periodicals, Inc.