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Structure and function of mycobacterium glycopeptidolipids from comparative genomics perspective
Author(s) -
Pang Lei,
Tian Xuelian,
Pan Weihua,
Xie Jianping
Publication year - 2013
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24515
Subject(s) - glycolipid , mycobacterium tuberculosis , cell envelope , biofilm , function (biology) , motility , phenotype , microbiology and biotechnology , chemistry , mycobacterium , biology , biochemistry , computational biology , bacteria , gene , tuberculosis , genetics , escherichia coli , medicine , pathology
Glycopeptidolipids (GPLs) attached to the outer surface of the greasy cell envelope, are a class of important glycolipids synthesized by several non‐tuberculosis mycobacteria. The deletion or structure change of GPLs confers several phenotypical changes including colony morphology, hydrophobicity, aggregation, sliding motility, and biofilm formation. In addition, GPLs, particular serovar specific GPLs, are important immunomodulators. This review aims to summarize the advance on the structure, function and biosynthesis of mycobacterium GPLs. J. Cell. Biochem. 114: 1705–1713, 2013. © 2013 Wiley Periodicals, Inc.