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Advance in research of microRNA in Caenorhabditis elegans
Author(s) -
Liu Jing,
Yang Baofeng,
Ai Jing
Publication year - 2013
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24448
Subject(s) - caenorhabditis elegans , microrna , biology , function (biology) , rna interference , computational biology , genetics , gene , rna
microRNA (miRNA) is a family of small, non‐coding RNA first discovered as an important regulator of development in Caenorhabditis elegans ( C. elegans ). Numerous miRNAs have been found in C. elegans , and some of them are well conserved in many organisms. Though, the biologic function of miRNAs in C. elegans was largely unknown, more and more studies support the idea that miRNA is an important molecular for C. elegans . In this review, we revisit the research progress of miRNAs in C. elegans related with development, aging, cancer, and neurodegenerative diseases and compared the function of miRNAs between C. elegans and human. J. Cell. Biochem. 114: 994–1000, 2013. © 2012 Wiley Periodicals, Inc.