Premium
Epigenetic modulation by TFII‐I during embryonic stem cell differentiation
Author(s) -
Bayarsaihan Dashzeveg,
Makeyev Aleksandr V.,
Enkhmandakh Badam
Publication year - 2012
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24202
Subject(s) - h3k4me3 , epigenetics , biology , embryonic stem cell , chromatin , stem cell , cellular differentiation , bivalent chromatin , transcription factor , gene , genome , genetics , microbiology and biotechnology , embryogenesis , promoter , gene expression , chromatin remodeling
TFII‐I transcription factors play an essential role during early vertebrate embryogenesis. Genome‐wide mapping studies by ChIP‐seq and ChIP‐chip revealed that TFII‐I primes multiple genomic loci in mouse embryonic stem cells and embryonic tissues. Moreover, many TFII‐I‐bound regions co‐localize with H3K4me3/K27me3 bivalent chromatin within the promoters of lineage‐specific genes. This minireview provides a summary of current knowledge regarding the function of TFII‐I in epigenetic control of stem cell differentiation. J. Cell. Biochem. 113: 3056–3060, 2012. © 2012 Wiley Periodicals, Inc.