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Assessing iPSC reprogramming methods for their suitability in translational medicine
Author(s) -
Rao Mahendra S.,
Malik Nasir
Publication year - 2012
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24183
Subject(s) - reprogramming , induced pluripotent stem cell , regenerative medicine , somatic cell , computational biology , translational medicine , biology , computer science , microbiology and biotechnology , stem cell , cell , embryonic stem cell , genetics , gene
The discovery of the ability to induce somatic cells to a pluripotent state through the overexpression of specific transcription factors has the potential to transform the ways in which pharmaceutical agents and cellular transplantation therapies are developed. Proper utilization of the technology to generate induced pluripotent stem cells (iPSCs) requires that researchers select the appropriate reprogramming method for generating iPSCs so that the resulting iPSCs can be transitioned towards clinical applications effectively. This article reviews all of the currently available reprogramming techniques with a focus on critiquing them on the basis of their utility in translational medicine. J. Cell. Biochem. 113: 3061‐3068, 2012. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.