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Spectrum of neuroendocrine differentiation in lung cancer cell lines featured by cytomorphology, markers, and their corresponding tumors
Author(s) -
Linnoila R. Ilona
Publication year - 1996
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240630506
Subject(s) - neuroendocrine differentiation , lung cancer , carcinogenesis , cell culture , pathology , cell , neuroendocrine cell , biology , cancer research , large cell , neuroendocrine tumors , small cell lung carcinoma , cellular differentiation , cancer , medicine , small cell carcinoma , immunohistochemistry , adenocarcinoma , genetics , gene , prostate cancer
Lung cancer cell lines which show features of neuroendocrine (NE) differentiation can be divided into 4 types which have distinct clinicopathologic correlates: classic small cell lung cancer (SCLC), variant SCLC, pulmonary carcinoid, and non‐small cell lung cancer with NE features (NSCLC‐NE). These cell lines form a spectrum regarding their degree of NE differentiation which ranges from high levels seen in carcinoid cell lines to very low which is typical of the variant SCLC. A careful comparison of the properties of tumors and their cell lines and correlating these data with the clinical history of the patient has markedly enhanced the relevance of cell lines as models for NE biology and lung carcinogenesis. © 1996 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.