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Quantitative cytopathology of endometrial lesions
Author(s) -
Tezuka Fumiaki,
Chiba Ryoji,
Takahashi Tohru
Publication year - 1995
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240590919
Subject(s) - cytopathology , malignancy , pathology , medicine , cytology
Morphometric and multivariate statistical methods were used to discriminate endometrial carcinoma from bengin cells in cytologic studies. Clumps of epithelial cells that appeared most diagnostically relevant were selected from aspirated sample of 70 endometrial cancer patients. The cells'cytologic character was reduced to a combination of five quantitive parameters—nuclear size, degree of anisokaryosis, nuclear from index, homogeneity of nuclear chromatin texture, and regularity of nuclear arrangement. The 5‐variate cluster analysis demonstrated that the 70 cases could be classified into three definite groups: Group A (17 cases) was characterzied by cells of small nuclear size, slight anisokaryosis, homogeneous chormatin texture and regular arrangment; Group C (12 cases) by cells of large nuclear size, marked anisokaryosis, heterogeneous chromatin texture, and irregular nuclear arrangement; and Group B (41 cases) by cells of parametere value. Group C was derived from 10 cases of adenocarcinoma and 2 of atypical hyperplasis, while groups A and B were not derived from any cases of malignancy. The computer‐assisted morphometric statistical method can objectively classify the endometrials cells into malignant and begin, with improved validity and reproducibility. The cytopathologic finding, if detected by this mathod, may serve as a surrogate endpoint biomarker.