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Oscillatory behavior of control‐systems of calcium homeostasis in chickens
Author(s) -
Hurwitz S.,
Miller Barbara,
Norman A. W.
Publication year - 1994
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240560218
Subject(s) - calcium , endocrinology , homeostasis , medicine , calcium metabolism , kidney , period (music) , chemistry , biology , physics , acoustics
Computer simulation of calcium homeostasis in chicks predicted an oscillatory behavior of bone calcium flow and kidney 25‐hydroxyvitamin D 3 ‐1 hydroxylase with a periodicity of 56 h and a 9 h phase difference between the two signals. In growing chickens subjected to a light: dark cycle of 22:2 h, and intravenously dosed with 45 Ca, the temporal changes in plasma 45 Ca could be described by an exponential decline with superimposed diurnal oscillations. The activity of the renal 25‐hydpoxyvitamil D 3 ‐1‐hydroxylase in chicks subjected to a 12:12 h light: dark cycle ALSO followed diupnal oscillations, with a ladir at the beginning of the light period and a peak 12 h later. The production of 1,25‐dihydroxyvitamin D 3 by primary cultures of chicken kidney cells mscillated with a periodicity of 5.6 h or shorter. It is suggested that despite the differences in phase and periodicity between the simulation predictions and actual results, the oscillations in both 1‐hydroxylase and bone calcium flow could be coupled through the hormonal systems involved in regulation of plasma calcium.