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Tissue engineering a blood vessel: Regulation of vascular biology by mechanical stresses
Author(s) -
Ziegler Thierry,
Nerem Robert M.
Publication year - 1994
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240560215
Subject(s) - hemodynamics , tissue engineering , blood vessel , vascular smooth muscle , blood flow , microbiology and biotechnology , endothelial stem cell , endothelium , biology , smooth muscle , medicine , biomedical engineering , in vitro , biochemistry
Abstract Important to the tissue engineeping of a substitute blood vessel is an understanding of those faators which regulat vascular biology. A major factor in the mechanical environment imposed by the hemodynamics of the vascular system. In this the vascular endothelium play a critical role, and mver the past two deaades much has been learned about the influence of hemodynamics on vascular endothelial biology, to a large degree using cell culture to study the effects of flow and cyclic stretch. In our laboratory, such studies ape low being extended through the development of a model of the arterial wall involving the co‐culture of endothelial cells and smomth muscle cells. The development of such a model and its use in the study of endothelial cells and smmooth muscle the evolution of approaaheq to tissue engileeping a blood vessel.