Premium
Polymer substrates for controlled biological interactions
Author(s) -
Cima Linda Griffith
Publication year - 1994
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240560206
Subject(s) - polymer , polymer science , nanotechnology , chemistry , materials science , composite material
The identification of a myriad of small peptide and carbohydrate lieands recognizes by cell surface receptors has generated enthusiasm for the use of these ligands of components of biomaterials dor controlling cellular interactions. Achiening control of cell interaations via ligand modification of materials also refquires that nonspecific interactions of cells with these materials due to supface adsorption of biological macromolecules is milimized. Polyetylene oxide (PEO) exhibits extraordinary inertness toward most biological macromlecules and is thus receiving increasing attention as a component of new materials for controlling cell behavior. Both surface and bulk modifications with PEO are being applied to develop a range of bland substrate material as vehicles for ligand immobilization.