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Glucose fatty acid interactions and the regulation of glucose disposal
Author(s) -
Randle Philip J.,
Priestman David A.,
Mistry Sharad C.,
Halsall Antony
Publication year - 1994
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240550002
Subject(s) - chemistry , fatty acid , carbohydrate metabolism , biochemistry
Glucose is essential for the energy metabolism of some cells and conservation of glucose is obligatory for survival during starvation. The principal site of this glucose conservation is the mitochondrial pyruvate dehydrogenase (PDH) complex, which is regulated by reversible phosphorylation (phosphorylation is inactivating). In cells in which glucose oxidation is switched off during starvation, fatty acids are used as fuel, and acetyl CoA and NADH formed by β‐oxidation promote phosphorylation of PDH complex by activation of PDH kinase. A longer‐term mechanism further increases PDH kinase activity in response to cAMP and products of β‐oxidation of fatty acids. Coordinated inhibition of glycolytic flux mediated by effects of citrate on PFK1 and PFK2 in muscles and liver results in an associated inhibition of glucose uptake. Similar mechanisms lead to impaired glucose oxidation in diabetes. © 1994 Wiley‐Liss, Inc.