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Histone H1t: A tissue‐specific model used to study transcriptional control and nuclear function during cellular differentiation
Author(s) -
Wolfe Steven A.,
Grimes Sidney R.
Publication year - 1993
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240530208
Subject(s) - histone , histone h2a , biology , histone h1 , sap30 , histone code , microbiology and biotechnology , gene , genetics , nucleosome
One of the most prominent and best studied family of genes is the histone gene family. In recent years, histone gene regulation during the cell cycle of somatic cells has been studied extensively. This paper is intended to highlight and emphasize recent data concerning the tissue‐specific expression of histone H1t using spermatogenesis as a model system. In this article we describe a unique DNA element within the proximal promoter of the histone H1t gene. This element has been shown to bind exclusively to nuclear proteins from pachytene spermatocytes and early spermatids. Thus, there is a strong temporal correlation between the appearance of the testis‐specific DNA‐binding protein and the onset of transcription of the testis‐specific histone H1t gene.