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Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones
Author(s) -
Kardalinou Efterpi,
Eick Stefan,
Albig Werner,
Doenecke Detlef
Publication year - 1993
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240520402
Subject(s) - pseudogene , cosmid , gene cluster , biology , gene , genetics , histone h1 , histone , histone h2a , microbiology and biotechnology , genome
A cluster of human histone genes was found on three overlapping clones isolated from cosmid and bacteriophage libraries. These three overlapping segments of the human genome comprise genes coding for H3.1, an H2A pseudogene, and an H2B.1 gene downstream of the previously characterized H1.2 gene. The cosmid clone covers 30 kb upstream of the H1.2 gene and overlaps with two phage clones covering the core histone genes and the pseudogene. The same arrangement of an H3 gene, an H2A pseudogene and an H2B gene downstream of an H1 gene has been described within a mouse histone gene cluster [Yang et al.: J Biol Chem 262:17118–17125, 1987; Gruber et al.: Gene 95:303–304, 1990].