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Protein kinase C: Mediator or inhibitor of insulin action?
Author(s) -
Considine R. V.,
Caro J. F.
Publication year - 1993
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240520103
Subject(s) - ask1 , mediator , insulin receptor , protein kinase a , insulin , cyclin dependent kinase 9 , grb10 , insulin resistance , mitogen activated protein kinase kinase , signal transduction , biology , microbiology and biotechnology , kinase , endocrinology
Abstract The role of protein kinase C in insulin signal transduction i s controversial It has been postulated that protein kinase C i s activated by insulin and that the kinase i s directly involved in insulin‐mediated metabolic processes. In opposition to this view i s the hypothesis that protein kinase C is not activated by insulin and, more importantly, may be responsible for attenuation of the insulin signal The evidence for and against protein kinase C as a mediator of the insulin signal will be put in perspective followed by discussion of the possible role of the kinase in the pathogenesis of insulin resistance in type II diabetes.