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Mechanisms of transcriptional activation by steroid hormone receptors
Author(s) -
Baniahmad Aria,
Tsai MingJer
Publication year - 1993
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240510206
Subject(s) - hormone , receptor , hormone receptor , microbiology and biotechnology , steroid hormone , nuclear receptor , agonist , biology , transcription factor , hormone response element , steroid , chemistry , endocrinology , estrogen receptor , biochemistry , gene , genetics , cancer , breast cancer
Steroid hormones are involved in cell growth, development, and differentiation. The hormonal signal is mediated by nuclear receptors which represent a specific class of transcription factors. During the last few years, the cloning of all the major steroid hormone receptors increased our insight into how the hormonal signal converts the receptor into a transcriptional activator. Good progress has been made towards understanding the mechanism of steroid hormone action. In this review we will discuss the role of heat shock proteins in the process of transcriptional activation, the mechanistic differences between the hormone (agonist) and the antihormone (antagonist), the resulting functional consequences, and a possible mode by which transcriptional activation is mediated. © 1993 Wiley‐Liss, Inc.