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Eukaryotic‐like protein serine/threonine kinases in Myxococcus xanthus , a developmental bacterium exhibiting social behavior
Author(s) -
MunozDorado Jose,
Inouye Sumiko,
Inouye Masayori
Publication year - 1993
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240510107
Subject(s) - myxococcus xanthus , dictyostelium discoideum , kinase , threonine , serine , biology , multicellular organism , microbiology and biotechnology , protein kinase a , protein serine threonine kinases , biochemistry , phosphorylation , gene , mutant
Myxococcus xanthus , a gram‐negative bacterium exhibits a spectacular life cycle and social behavior. Its developmental cycle and multicellular morphogenesis resemble those of eukaryotic slime molds such as Dictyostelium discoideum . On the basis of this resemblance, we explored the existence of eukaryotic‐like protein serine/threonine kinases which are known to play important roles in signal transduction during development of D. discoideum . It was indeed found that M. xanthus contains a large family of protein serine/threonine kinases related to the eukaryotic enzymes. This is the first unambiguous demonstration of eukaryotic‐like protein serine/threonine kinases in the prokaryotes. © 1993 Wiley‐Liss, Inc.